Genetic Association Between NRXN3 Variants (rs12879016 & rs2270964) and Risk of Schizophrenia (SCZ)

Abdulmajeed Saleh Alzahrani, Wael Salah Alhazmi, Mohammad Talal Dandini, Maher Mohammed Alsubhi, Mohammed Ali Mohammed Alghamdi; Rayid Shabib Mofareh Alotaibi, Marzouq Mohsen Alnefaie, Faris Khader Hasan Alhassani, Fahad Mansour Alhulayfi, Mutlaq Dakhel Fawaz Almalki

doi:10.63278/jicrcr.vi.963

Genetic Association Between NRXN3 Variants (rs12879016 & rs2270964) and Risk of Schizophrenia (SCZ)

Authors

Abdulmajeed Saleh Alzahrani, Wael Salah Alhazmi, Mohammad Talal Dandini, Maher Mohammed Alsubhi, Mohammed Ali Mohammed Alghamdi
Rayid Shabib Mofareh Alotaibi, Marzouq Mohsen Alnefaie, Faris Khader Hasan Alhassani, Fahad Mansour Alhulayfi, Mutlaq Dakhel Fawaz Almalki

DOI:

https://doi.org/10.63278/jicrcr.vi.963

Abstract

There hasn't been much study on the link between schizophrenia (SCZ) and neurexin 3 (NRXN3) genetic variations. The first association study of the NRXN3 rs12879016 G>C,T and rs2270964 C>A,T single-nucleotide polymorphisms (SNP)in a Saudi population is shown here.
We used real-time PCR to assess the genotypes for the polymorphisms in one hundred seventeen patients with SCZ and Seventy-eight healthy controls. We used endonuclease digestion of amplified genomic DNA to establish the genotypes for the polymorphisms in 117 patients with DSM-IV and PANSS (Positive and Negative Syndrome Scale) evaluations of schizophrenia and 78 healthy controls.
We aim to find out if there is a relation between NRXN3 variations (rs12879016 and rs2270964) and susceptibility of developing SCZ in a Saudi population.
We hypothesis that SCZ can be related to patients with NRXN3 variations (rs12879016 / rs2270964) among Saudi population.
According to our result both rs12879016 and rs2270964 polymorphisms were shown to be unrelated to the risk of schizophrenia.

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Published

2024-09-15

How to Cite

Abdulmajeed Saleh Alzahrani, Wael Salah Alhazmi, Mohammad Talal Dandini, Maher Mohammed Alsubhi, Mohammed Ali Mohammed Alghamdi, & Rayid Shabib Mofareh Alotaibi, Marzouq Mohsen Alnefaie, Faris Khader Hasan Alhassani, Fahad Mansour Alhulayfi, Mutlaq Dakhel Fawaz Almalki. (2024). Genetic Association Between NRXN3 Variants (rs12879016 & rs2270964) and Risk of Schizophrenia (SCZ). Journal of International Crisis and Risk Communication Research , 2109–2138. https://doi.org/10.63278/jicrcr.vi.963