Levofloxacin and Ciprofloxacin in the treatment of urinary tract infection

Abstract

Background: Urinary tract infections (UTIs) are one of the most frequent bacterial infections acquired in both hospital and community.
Aim: To compare between levofloxacin and ciprofloxacin in the management of urinary tract infections would typically be to compare and assess the safety, efficacy, and tolerability of these two antibiotics in treating UTIs caused by common bacterial pathogens.
Patients and methods: This systematic review and meta-analysis search were carried out across multiple databases, involving Cochrane Library, PubMed, and Embase, to identify relevant randomized controlled trials (RCTs). The included data from four studies conducted between 2003 and 2012, with a total of 1127 patients.
Results: Two studies reported (Headache) and all can be used. A no significant heterogeneity has been identified. Consequently, a random-effect model has been used for analysis (I² = 0%, P=0.32). The combined mean difference and ninety-five percent CIs was 0.78 (0.35 to 1.72). The combined result demonstrates statistically no significant difference between groups regarding (Headache) (Z= 0.62, P=0.54).
Two studies reported (Dizziness) and all can be used. A significant heterogeneity was detected. Therefore, a random-effect model was used for analysis (I² = 73%, P-value equals 0.05). The combined mean difference and ninety-five percent CIs was 0.43 (0.12 to 1.53). The combined result demonstrates statistically insignificant distinction among groups regarding (Dizziness) (Z-value equals 1.30, P-value equals 0.19).
Conclusion: Both levofloxacin and ciprofloxacin are effective in treating UTI, with no significant difference in clinical success rate, microbial eradication rate, or adverse event rate.