Pharmacological agonists of the Apelin (APJ) Receptor, reviewing mechanism of action

Bijad Helal F Alotibi, Mohammed obaid aifan alotaibi, Yousef Hussain Hamoud Alotaibi, Omar abdu hamd alribi,  Yara Ramzi Yosef Kamfar; Abdullah Fisal Al-Hazmi, Khadijah Zakarya Imam, Wajeeh Rahem AlMalkei, Ibrahim dawy almoqaty, SULTAN NASSER ALZAHRANI

doi:10.63278/jicrcr.vi.794

Pharmacological agonists of the Apelin (APJ) Receptor, reviewing mechanism of action

Authors

Bijad Helal F Alotibi, Mohammed obaid aifan alotaibi, Yousef Hussain Hamoud Alotaibi, Omar abdu hamd alribi, Yara Ramzi Yosef Kamfar
Abdullah Fisal Al-Hazmi, Khadijah Zakarya Imam, Wajeeh Rahem AlMalkei, Ibrahim dawy almoqaty, SULTAN NASSER ALZAHRANI

DOI:

https://doi.org/10.63278/jicrcr.vi.794

Abstract

The Apelin receptor (APJ), a G protein-coupled receptor (GPCR), is activated by the endogenous peptide apelin and plays a significant role in various physiological processes, including cardiovascular regulation, fluid homeostasis, energy metabolism, and angiogenesis. Pharmacological agonists of the APJ receptor have emerged as potential therapeutic agents for treating conditions such as heart failure, pulmonary hypertension, and metabolic disorders. This review explores the mechanisms of action of APJ receptor agonists, highlighting their pharmacodynamics, downstream signaling pathways, and therapeutic implications. Additionally, it examines advancements in the development of synthetic APJ agonists and their clinical potential.

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Published

2024-08-22

How to Cite

Bijad Helal F Alotibi, Mohammed obaid aifan alotaibi, Yousef Hussain Hamoud Alotaibi, Omar abdu hamd alribi, Yara Ramzi Yosef Kamfar, & Abdullah Fisal Al-Hazmi, Khadijah Zakarya Imam, Wajeeh Rahem AlMalkei, Ibrahim dawy almoqaty, SULTAN NASSER ALZAHRANI. (2024). Pharmacological agonists of the Apelin (APJ) Receptor, reviewing mechanism of action. Journal of International Crisis and Risk Communication Research , 659–663. https://doi.org/10.63278/jicrcr.vi.794