Updates in Diagnostic Challenges and Management of Breast Cancer Recurrence after Breast Reconstruction Surgery: A Systematic Review

Abstract

Background: Breast reconstruction surgery, although a valuable option for enhancing quality of life post-mastectomy, has been historically associated with concerns regarding cancer recurrence and long-term survival. Study Aim: This systematic review aimed to synthesize the most updated evidence regarding breast cancer recurrence after breast reconstruction surgery, focusing on diagnostic challenges and management strategies. Methodology: A thorough search strategy was utilized to find pertinent studies that were published up to 15 September 2022, utilizing databases such as MEDLINE,the Cochrane Library, and Embase. No statistical software was used as the study was based on qualitative data synthesis. Results: The systematic review included Nine cohort studies conducted retrospectively, among 29,058 with breast cancer the comprising include 2781 cases of breast reconstruction .Analysis revealed a doubling in immediate reconstruction rates over the past two decades, influenced by variables like age, income, insurance status, place of residence, and type of mastectomy. Importantly, No notable variances were observed in the perspective of overall survival, survival Precise to breast cancer, or recurrence rates among women who underwent reconstruction compared to those who did not undergo reconstruction, whether immediately or with a delay. The overall risk of bias across the included studies was found to be low by using the Cochrane Risk of Bias tool. Conclusion: The findings of this systematic review suggest that breast reconstruction, whether performed immediately or delayed, Doesn't negatively influence oncological outcomes in terms of recurrence rates or survival. Future research should focus on longer follow-up periods of prospective studies to further validate these findings and refine clinical guidelines for optimal patient care.