Assessment of Left Ventricular Systolic Function in Type 2 Diabetic Patients with Nonalcoholic Fatty Liver Disease Using Three- dimensional Speckle-Tracking Echocardiography

Abstract

Background: Non-alcoholic fatty liver disease (NAFLD) is the commonest liver affection that linked with type II DM and much researches take into account NAFLD as one of risk factors of cardiovascular affection in type II DM patients. So in our study we aimed to detect the early affection of LV functions in patients with type II DM and NAFLD, by using speckle tracking imaging.
Methods: This study was a patient-control study conducted on 200 type 2 diabetic patients divided into two groups; 100 patients with moderate to severe NAFLD (cases) and 100 patients without NAFLD (control), all patients underwent Abdominal ultrasound to diagnose fatty liver and evaluation of LV functions by using 3D speckle tracking imaging.
Results: 2DEF, 3DEF, GLS, GRS, GCS, and GAS of the cases were significantly lower than the control group (P value <0.05). There is a significant negative correlation between BMI, HbA1c, cholesterol, triglycerides, AST, ALT, and HOMA- IR and between all 3D strain domains (GLS, GRS, GCS, and GAS) of type 2 DM.
Conclusion: LV systolic function was affected sub-clinically in Egyptian Type 2 diabetic patients with nonalcoholic fatty liver disease (NAFLD) using 3D-STE. 3D- STE can be used effectively as an essential and also noninvasive technique in order to evaluate LV function in NAFLD with T2DM.