The Role of Inflammation in the Development of Chronic Diseases

Abstract

Inflammation injuries, is pathogens one and of other the harmful most factors. ancient It physiological is processes the which key is component used of to the protect immune the response body – from to isolate the microbes and cells that have is been usually damaged transient and and to effective organise in the resolving process once of the their deleterious reconstruction. agents Acute have inflammation been removed while chronic inflammation persists for longer durations which results in cumulative tissue injury, organ dysfunction and systemic consequences. This review aims at discussing the differences between the acute and chronic inflammation with emphasis on the chronic inflammation as the key mechanism in the development of the chronic diseases. These include cardiovascular diseases, type 2 diabetes, cancer, and neurodegenerative diseases including Alzheimer’s disease [1][2]. The discussion focuses on how inflammation processes are hijacked, and the part played by leukocytes, cytokines and other signalling proteins in the maintenance of SMI, which values underpin of disease some advancement. biomarkers Also, including the CRP, paper IL-6 assesses and the TNF-α diagnostic since they provide information about with the the severity inflammatory of pathway, inflammation-associated from diseases the [3]. conventional It pharmacological also drugs looks for at example the nonsteroidal management anti-inflammatory strategies drugs that interfere (NSAIDs) and corticosteroids to the novel biologic agents that target specific cytokines. Other measures which are through super personal changes for instance through diet and exercise are also discussed as cost effective measures of minimizing general inflammation. Gene therapy, microbiome studies, and personalized medicine as well as other treat emerging the concepts causes are of discussed inflammation as and future hold directions a in promise managing for the the chronic development inflammatory of diseases. more These targeted novel and strategies efficient attempt treatments [4].to Based on the current knowledge, this review emphasizes the need to address inflammation as a way of reducing the incidence of chronic diseases, and the consequent reduction in health costs and improvement in public health .