Evaluation of Rheum aqueous extract effects on liver function in valproic acid-induced hepatotoxicity in rat model
DOI:
https://doi.org/10.63278/jicrcr.vi.2583Abstract
Introduction: Valproic acid (VPA) is the major drug used to treat epilepsy and neurological disorders. However, liver damage is a negative side effect associated with VPA. The liver function plays a significant role in hepatotoxicity induced by VPA.
Objectives: The current study was conducted to evaluate if L-carnitine and aqueous extract of rheum (Rhubarb) reducing agents have any benefits against hepatotoxicity induced by VPV.
Methods: Animals were divided into five groups and cytotoxicity markers were assessed. Moreover, animals in the first group received 1 ml distilled water per animal for 15 days, the second group received VPA orally at a dose of 250 mg/kg/day for 20 consecutive days, the third group received L-carnitine orally at a dose of 250 mg/kg/day for 15 consecutive days) after induction by VPA, the fourth group received Rhubarb aqueous extract 80mg/kg /day; orally for 15 consecutive days) after induction by VPA, and the fifth group received a mixture of L-carnitine and Rhubarb extract after induction by VPA.
Results: A dosage of 250 mg of VPA significantly elevated markers of liver function like ALT, AST, and ALP. Using an aqueous extract of Rhubarb elucidates a hepatoprotective effect compared to the standard drug of L-carnitine.
Conclusions: Using L-carnitine, Rhubarb aqueous extract, and the mixture of L-carnitine and Rhubarb aqueous extract decreases ALP, ALT, and AST levels. Histopathological changes in the oxidative stress and liver function markers were observed in VPA-treated animals. The findings from this study highlight the potential therapeutic activities of Rhubarb aqueous extract in mitigating VPA-induced liver injury