NLRP3 inflammasome as a therapeutic target in cardiovascular diseases: An update of preclinical and clinical evidence

Abstract

The role of inflammation in the pathogenesis of various diseases is of paramount importance, with a significant impact on morbidity and mortality. This underscores the pivotal role of cardiovascular diseases as the leading cause of mortality globally, including in Chile. In this context, the NLRP3 inflammasome, a multiprotein complex of the innate immune system, has been the subject of intense research with regard to its expression and activation in cardiovascular pathologies. The present review addresses the preclinical and clinical scientific evidence, using databases and proceeded to classify the collected molecules according to their mechanism of inhibition of NLRP3 inflammasome activation, exploring their potential therapeutic effect in cardiovascular diseases. In conclusion, it is highlighted that the molecules currently under study show significant improvements in cardiovascular disease symptoms by influencing the priming or activation of the NLRP3 inflammasome.
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