Evidence-Based Research and Clinical Application of Adverse Reactions and Management Strategies for Cancer Treatment Drugs

Abstract

Although chemotherapy-associated adverse events are important in oncology practice and there are many different interventions to reduce them, there have been few systematic attempts to identify, critically evaluate, and compile all of the evidence regarding the effectiveness of these interventions. Survivors may encounter adverse effects during and after therapy, or they may manifest throughout the months and years following treatment. The most popular pharmaceutical and non-pharmacological therapeutic approaches, Guidelines for evidence-based clinical practicefor their proper management, and the molecular mechanisms underlying each of these side effects are all discussed and critically assessed by researchers. Researchers also go over risk variables and validated risk-assessment tools for determining which individuals are most likely to suffer side effects from chemotherapy and which ones can benefit from successful therapies. Lastly, experts point to promising new supportive care options for the growing number of cancer survivors who are still at risk for negative side effects after their treatments.