Diagnostic Test Accuracy of Multiparametric Magnetic Resonance Imaging with Endorectal Coil in Detection of Prostate Cancer: Meta-Analysis

Abstract

Background: Prostate cancer is a significant global health concern, and early detection is pivotal for improved patient outcomes. Multiparametric magnetic resonance imaging (MRI) with an endorectal coil has emerged as a valuable tool for prostate cancer diagnosis. This systematic review and meta-analysis aim to comprehensively evaluate the diagnostic test accuracy of multiparametric MRI in detecting prostate cancer.
Methods: A systematic literature search was conducted to identify relevant studies. Fifteen studies meeting inclusion criteria were selected, representing diverse patient populations and clinical settings. Data were extracted for sensitivity, specificity, positive predictive value, and negative predictive value. A meta-analysis was performed to calculate pooled diagnostic performance estimates and assess publication bias.
Results: The pooled sensitivity was estimated at 86%, and specificity at 72%. The diagnostic odds ratio was 16, indicating good discriminatory ability. The area under the receiver operating characteristic (ROC) curve was 0.88, indicating favorable diagnostic performance. However, publication bias was detected (p = 0.01), emphasizing the need for cautious interpretation of results.
Conclusion: This meta-analysis provides a comprehensive assessment of the diagnostic test accuracy of multiparametric MRI in prostate cancer detection. It highlights the potential of this imaging modality as a valuable diagnostic tool, although ongoing efforts are needed to refine its diagnostic performance and minimize false positives. In clinical practice, multiparametric MRI should be integrated into a comprehensive diagnostic approach, considering individual patient risk factors and clinical context.