A Comprehensive Review of Non-Steroidal Anti-Inflammatory Drug bioavailability in Elderly patients

Abstract

Aim: To examine the bioavailability of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) in elderly patients and its implications for clinical practice.
NSAIDs are widely used for managing chronic pain and inflammation in elderly patients. Age-related physiological changes, including altered gastrointestinal absorption, hepatic metabolism, and renal clearance, significantly affect NSAID bioavailability and therapeutic outcomes. These changes increase the risk of adverse effects, such as gastrointestinal bleeding, renal toxicity, and cardiovascular complications, particularly in the context of polypharmacy and comorbidities. This review highlights the pharmacokinetic and pharmacodynamic variations in elderly patients and emphasizes the need for individualized dosing, regular monitoring, and the use of adjunctive therapies to optimize NSAID safety and efficacy.