Screening using laboratory parameters for lipid disorders in the pediatrics: Systematic Review and Meta-Analysis

Abstract

Background: Familial hypercholesterolemia (FH) is a prevalent genetic illness that worsens atherosclerotic cardiovascular disease (ASCVD) because of an increased concentration of low-density lipoprotein (LDL) and cholesterol (LDL-C).
Aim: To evaluate the efficiency of screening using laboratory parameters for lipid disorders in pediatric populations, particularly focusing on the sensitivity of family history (FH) of dyslipidemia versus familial hypercholesterolemia of premature cardiovascular disease (CVD) in predicting dyslipidemia in children.
Patients and methods: The search strategy for this systematic review has been designed to ensure a comprehensive identification of relevant investigations. Databases Searched, electronic databases have been searched, including: PubMed, EMBASE, Cochrane Library and google Scholar. A combination of keywords and Medical Subject Headings (MeSH) terms have been used to capture all relevant studies. "Pediatric" OR "Children" OR "Adolescents
Results: The search strategy for this systematic review has been designed to ensure a comprehensive identification of relevant studies. Databases Searched, electronic databases have been searched, including: PubMed, EMBASE, Cochrane Library and google Scholar. A combination of keywords and Medical Subject Headings (MeSH) terms have been used to capture all relevant studies. "Pediatric" OR "Children" OR "Adolescents. Risk of bias of our six investigations has been evaluated by ROB1, most of our studies show high risk as regard detection biases and attrition biases and unclear risk regarding other biases
Conclusion: A family history of dyslipidemia is a stronger predictor of dyslipidemia in children, with a 6.9% higher sensitivity. However, heterogeneity suggests varying factors influencing LDL cholesterol levels.