An Overview of Genetic Biomarkers Influencing Drug Response and Efficacy in Specific Populations

Nourah Gherman Salman Al-Amri, Aljohara Mohammed Hasan Halikah, Sharif Wusayman Lafi Alharbi, Mohammed Obaidallah Obaid Almatrafi, Ahmed Habib Aelnakhly, Nabial Hamadi Al Sheikh, Najat Khalaf Almashyakhi, Khaled Mohammed Hamed Alamri; Mahmoud Khamis Saeed Alghamdi, Ismaeel Mohamed Sardar, Abdullah Hassan Alhumrani, Ahmad Khalid Damanhouri, Rasheed Saeed Ali Alghamdi, Waad Hamed Alsharif, Abdulaziz Faihan Mashan Alotaibi

doi:10.63278/jicrcr.vi.1211

An Overview of Genetic Biomarkers Influencing Drug Response and Efficacy in Specific Populations

Authors

Nourah Gherman Salman Al-Amri, Aljohara Mohammed Hasan Halikah, Sharif Wusayman Lafi Alharbi, Mohammed Obaidallah Obaid Almatrafi, Ahmed Habib Aelnakhly, Nabial Hamadi Al Sheikh, Najat Khalaf Almashyakhi, Khaled Mohammed Hamed Alamri
Mahmoud Khamis Saeed Alghamdi, Ismaeel Mohamed Sardar, Abdullah Hassan Alhumrani, Ahmad Khalid Damanhouri, Rasheed Saeed Ali Alghamdi, Waad Hamed Alsharif, Abdulaziz Faihan Mashan Alotaibi

DOI:

https://doi.org/10.63278/jicrcr.vi.1211

Abstract

This review examines the role of genetic biomarkers in influencing drug response and efficacy, focusing on their impact in specific populations and the challenges in implementing pharmacogenomics in clinical practice. Genetic biomarkers, such as polymorphisms in CYP450 enzymes, HLA alleles, and TPMT, significantly affect drug metabolism, efficacy, and the risk of adverse reactions. Population-specific genetic differences, such as HLA-B15:02 in Southeast Asians and CYP2C19 variants in East Asians, highlight the importance of tailoring pharmacogenomic insights to diverse groups. While pharmacogenomics holds immense promise for personalized medicine, barriers such as limited population diversity in genomic research, high testing costs, and integration challenges hinder its widespread application. Addressing these issues through collaborative efforts and advancing equitable access to genetic testing can unlock the potential of pharmacogenomics to optimize therapeutic outcomes and reduce disparities in healthcare.

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Published

2024-07-10

How to Cite

Nourah Gherman Salman Al-Amri, Aljohara Mohammed Hasan Halikah, Sharif Wusayman Lafi Alharbi, Mohammed Obaidallah Obaid Almatrafi, Ahmed Habib Aelnakhly, Nabial Hamadi Al Sheikh, Najat Khalaf Almashyakhi, Khaled Mohammed Hamed Alamri, & Mahmoud Khamis Saeed Alghamdi, Ismaeel Mohamed Sardar, Abdullah Hassan Alhumrani, Ahmad Khalid Damanhouri, Rasheed Saeed Ali Alghamdi, Waad Hamed Alsharif, Abdulaziz Faihan Mashan Alotaibi. (2024). An Overview of Genetic Biomarkers Influencing Drug Response and Efficacy in Specific Populations . Journal of International Crisis and Risk Communication Research , 9–14. https://doi.org/10.63278/jicrcr.vi.1211